Adaptation of Influenza H5N1 Vaccine Viruses in Vero Cells

Adaptation of High-Growth Influenza H5N1 Vaccine Virus in Vero Cells: Implications for Pandemic Preparedness

Current egg-based influenza vaccine production technology can't promptly meet the global demand during an influenza pandemic as shown in the 2009 H1N1 pandemic. Moreover, its manufacturing capacity would be vulnerable during pandemics caused by highly pathogenic avian influenza viruses. Therefore, vaccine production using mammalian cell technology is becoming attractive. Current influenza H5N1 ...

Pathogenic Avian Influenza Candidates against H5N1 Highly Containing NS1 Truncations as Vaccine Live Attenuated Influenza Viruses

Replication-Competent Neuraminidase-Negative Influenza H5N1 Viruses

H5N1 influenza viruses: facts, not fear.

The ongoing controversy over publication of two studies involving the transmission in ferrets of H5N1 (H5) subtype influenza viruses and the recommendations of the National Science Advisory Board for Biosecurity to redact key details in the manuscripts call for an examination of relevant scientific facts. In addition, there are calls in the media to destroy the viruses, curtail future research ...

Egyptian H5N1 Influenza Viruses—Cause for Concern?

1 Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, 3 Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, 4 ERATO InfectionInduced Host Responses Project, Saitama, Japan, 5 Department of Special Pat...